Human Multipotent Cell Conditioned Media (CCM): The liquid complex produced through Histogen’s manufacturing process contains soluble biologicals with a diverse range of embryonic-like proteins.  Because the cells produce and secrete these factors while developing the ECM, these proteins are naturally infused into the liquid media in a stabilized form.  The CCM contains a diverse mixture of cell-signaling materials, including human growth factors such as Keratinocyte Growth Factor, soluble human ECM proteins such as collagen, and vital proteins which support the epidermal stem cells that renew skin throughout life.

Human Extracellular Matrix (hECM): The hECM produced through Histogen’s proprietary process is a novel, all-human, naturally-secreted material.  It is most similar to early embryonic structural tissue which provides the framework and signals necessary for cell in-growth and tissue development.  By producing similar ECM materials to those that aided in the original formation of these tissues in the embryo, regenerative cells are supported in vitro and have shown potential as therapeutics in vivo.

Hair Stimulating Complex (HSC): HSC is a soluble biologic comprised of growth factors involved in the signaling of cells in the body, particularly those factors known to be important in hair formation and the stimulation of resting hair follicles.



More than 50 patents have been filed worldwide on Histogen’s technology and the compositions produced through its manufacturing process.

As of December 31, 2019, Histogen holds eight U.S. issued patents, 40 foreign issued patents and has 30 active patent applications in the US and elsewhere.